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TargetThyrotropin-releasing hormone receptor
LigandBDBM50072394
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303571
Ki 42±n/a nM
Citation Prokai, LProkai-Tatrai, KZharikova, ADNguyen, VPerjesi, PStevens, SM Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium. J Med Chem47:6025-33 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyrotropin-releasing hormone receptor
Name:Thyrotropin-releasing hormone receptor
Synonyms:TRH-R | Thyroliberin receptor
Type:PROTEIN
Mol. Mass.:46618.79
Organism:Rattus norvegicus
Description:ChEMBL_303571
Residue:412
Sequence:
MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTAT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKES
DRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50072394
NameBDBM50072394
Synonyms:1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide | A-38579 | ABBOTT-38579 | PROTIRELIN
TypeSmall organic molecule
Emp. Form.C16H22N6O4
Mol. Mass.362.3837
SMILESNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Structure
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