Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50156328
Substrate
n/a
Meas. Tech.
ChEMBL_305666 (CHEMBL827935)
IC50
2±n/a nM
Citation
 Luo, G; Mattson, GK; Bruce, MA; Wong, H; Murphy, BJ; Longhi, D; Antal-Zimanyi, I; Poindexter, GS Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists. Bioorg Med Chem Lett 14:5975-8 (2004) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50156328
Synonyms:
2,6-Dimethyl-4-[3-(3-{2-[1-(2-nitro-phenyl)-piperidin-4-ylamino]-ethyl}-ureido)-phenyl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | CHEMBL366340
Type:
Small organic molecule
Emp. Form.:
C31H38N6O7
Mol. Mass.:
606.6694
SMILES:
COC(=O)C1=C(C)[N-]C(C)=C(C1c1cccc(NC(=O)NCCNC2CCN(CC2)c2ccccc2[N+]([O-])=O)c1)C(=[OH+])OC |c:4,9|
Structure:
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