Target
Flap endonuclease 1
Ligand
BDBM50157850
Substrate
n/a
Meas. Tech.
ChEMBL_304960 (CHEMBL827838)
IC50
0.23±n/a nM
Citation
 Tumey, LNBom, DHuck, BGleason, EWang, JSilver, DBrunden, KBoozer, SRundlett, SSherf, BMurphy, SDent, TLeventhal, CBailey, AHarrington, JBennani, YL The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett 15:277-81 (2004) [PubMed]  Article 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM50157850
Synonyms:
3-Hydroxy-1-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL182974
Type:
Small organic molecule
Emp. Form.:
C13H10N2O3S
Mol. Mass.:
274.295
SMILES:
On1c(=O)n(Cc2ccccc2)c2sccc2c1=O
Structure:
Search PDB for entries with ligand similarity: