Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50153535
Substrate
n/a
Meas. Tech.
ChEMBL_430238 (CHEMBL914477)
IC50
130±n/a nM
Citation
 Zhao, H; Xin, Z; Liu, G; Schaefer, VG; Falls, HD; Kaszubska, W; Collins, CA; Sham, HL Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation. J Med Chem 47:6655-7 (2004) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50153535
Synonyms:
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-diethylamino-phenyl)-amide | CHEMBL178668
Type:
Small organic molecule
Emp. Form.:
C21H21Cl2N3O2
Mol. Mass.:
418.316
SMILES:
CCN(CC)c1ccc(NC(=O)c2c(C)onc2-c2c(Cl)cccc2Cl)cc1 |(7.8,-1.79,;6.33,-1.35,;5.95,.15,;7.07,1.22,;6.73,2.7,;4.47,.6,;3.4,-.45,;1.89,-.05,;1.51,1.42,;.02,1.81,;-1.09,.71,;-.67,-.78,;-2.57,1.11,;-2.95,2.6,;-2.02,3.81,;-4.5,2.67,;-5.04,1.23,;-3.84,.26,;-3.76,-1.28,;-2.39,-1.98,;-.84,-1.98,;-2.32,-3.53,;-3.58,-4.37,;-4.97,-3.67,;-5.06,-2.12,;-6.44,-1.45,;2.6,2.51,;4.05,2.12,)|
Structure:
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