Reaction Details Report a problem with these data
Target
Cytochrome P450 26A1
Ligand
BDBM50158410
Substrate
n/a
Meas. Tech.
ChEMBL_430395 (CHEMBL916379)
IC50
5.2±n/a nM
Citation
 Patel, JB; Huynh, CK; Handratta, VD; Gediya, LK; Brodie, AM; Goloubeva, OG; Clement, OO; Nanne, IP; Soprano, DR; Njar, VC Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. J Med Chem 47:6716-29 (2004) [PubMed]  Article 
Target
Name:
Cytochrome P450 26A1
Synonyms:
CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56216.16
Organism:
Homo sapiens (Human)
Description:
O43174
Residue:
497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
  
Inhibitor
Name:
BDBM50158410
Synonyms:
4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-retinamide | CHEMBL223072
Type:
Small organic molecule
Emp. Form.:
C26H32N4O
Mol. Mass.:
416.5585
SMILES:
C\C(\C=C\C1=C(C)C(CCC1(C)C)n1ccnc1)=C/C=C/C(/C)=C/C(=O)n1ccnc1 |c:4|
Structure:
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