Reaction Details Report a problem with these data
Target
Tubulin beta-1 chain
Ligand
BDBM50006675
Substrate
n/a
Meas. Tech.
ChEMBL_305199 (CHEMBL832453)
IC50
3400±n/a nM
Citation
 Ducki, S; Mackenzie, G; Lawrence, NJ; Snyder, JP Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem 48:457-65 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50006675
Synonyms:
5-[(Z)-2-(4-Ethyl-phenyl)-vinyl]-1,2,3-trimethoxy-benzene | 5-[2-(4-Ethyl-phenyl)-vinyl]-1,2,3-trimethoxy-benzene | CHEMBL75284
Type:
Small organic molecule
Emp. Form.:
C19H22O3
Mol. Mass.:
298.3762
SMILES:
CCc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1
Structure:
Search PDB for entries with ligand similarity: