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Target
Tubulin beta-1 chain
Ligand
BDBM50159318
Substrate
n/a
Meas. Tech.
ChEMBL_305199 (CHEMBL832453)
IC50
2000±n/a nM
Citation
 Ducki, S; Mackenzie, G; Lawrence, NJ; Snyder, JP Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem 48:457-65 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50159318
Synonyms:
(E)-3-(3''-Amino-4''-methoxyphenyl)-1-(3',4',5'-trimethoxyphenyl)prop-2-en-1-one | (E)-3-(3''-amino-4''-methoxyphenyl)-1-(3',4',5'-trimethoxyphenyl)-2-propen-1-one | (E)-3-(3-Amino-4-methoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone | (E)-3-(3-amino-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | CHEMBL427543
Type:
Small organic molecule
Emp. Form.:
C19H21NO5
Mol. Mass.:
343.3737
SMILES:
COc1ccc(\C=C\C(=O)c2cc(OC)c(OC)c(OC)c2)cc1N
Structure:
Search PDB for entries with ligand similarity: