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Target
Alpha-2A adrenergic receptor
Ligand
BDBM50077543
Substrate
n/a
Meas. Tech.
ChEMBL_303434 (CHEMBL839603)
Ki
4840±n/a nM
Citation
 Grunewald, GL; Romero, FA; Seim, MR; Criscione, KR; Deupree, JD; Spackman, CC; Bylund, DB Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Bioorg Med Chem Lett 15:1143-7 (2005) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
48979.91
Organism:
Homo sapiens (Human)
Description:
P08913
Residue:
450
Sequence:
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50077543
Synonyms:
3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline | 3-methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline | CHEMBL59719
Type:
Small organic molecule
Emp. Form.:
C10H12N2O2
Mol. Mass.:
192.2145
SMILES:
CC1Cc2ccc(cc2CN1)[N+]([O-])=O
Structure:
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