Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50161050
Substrate
n/a
Meas. Tech.
ChEMBL_306206 (CHEMBL830164)
IC50
>10000±n/a nM
Citation
 Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett 15:1201-4 (2005) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50161050
Synonyms:
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4-piperidin-1-yl-phenyl)-amide | CHEMBL368247
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N3O2
Mol. Mass.:
430.327
SMILES:
Cc1onc(c1C(=O)Nc1ccc(cc1)N1CCCCC1)-c1c(Cl)cccc1Cl |(-2.43,3.45,;-3.38,2.24,;-4.92,2.33,;-5.45,.89,;-4.27,-.08,;-2.99,.77,;-1.52,.37,;-1.11,-1.12,;-.41,1.46,;1.08,1.07,;1.83,2.43,;3.37,2.44,;4.15,1.11,;3.41,-.23,;1.87,-.24,;5.69,1.12,;6.46,2.47,;7.99,2.47,;8.77,1.16,;8.03,-.21,;6.49,-.21,;-4.18,-1.62,;-5.48,-2.47,;-6.86,-1.77,;-5.39,-4.01,;-4.01,-4.7,;-2.73,-3.87,;-2.8,-2.32,;-1.33,-2.71,)|
Structure:
Search PDB for entries with ligand similarity: