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Target
Hexokinase-4
Ligand
BDBM50161676
Substrate
n/a
Meas. Tech.
ChEMBL_304261 (CHEMBL829031)
EC50
16300±n/a nM
Citation
 Castelhano, AL; Dong, H; Fyfe, MC; Gardner, LS; Kamikozawa, Y; Kurabayashi, S; Nawano, M; Ohashi, R; Procter, MJ; Qiu, L; Rasamison, CM; Schofield, KL; Shah, VK; Ueta, K; Williams, GM; Witter, D; Yasuda, K Glucokinase-activating ureas. Bioorg Med Chem Lett 15:1501-4 (2005) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
Gck | HXK4_RAT | Hexokinase type IV
Type:
PROTEIN
Mol. Mass.:
52101.81
Organism:
Rattus norvegicus
Description:
ChEMBL_1279785
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
  
Inhibitor
Name:
BDBM50161676
Synonyms:
1-Cyclopentylmethyl-1-(3,4-difluoro-phenyl)-3-thiazol-2-yl-urea | CHEMBL181635
Type:
Small organic molecule
Emp. Form.:
C16H17F2N3OS
Mol. Mass.:
337.387
SMILES:
Fc1ccc(cc1F)N(CC1CCCC1)C(=O)Nc1nccs1
Structure:
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