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Target
Hexokinase-4
Ligand
BDBM50161681
Substrate
n/a
Meas. Tech.
ChEMBL_304261 (CHEMBL829031)
EC50
7700±n/a nM
Citation
 Castelhano, AL; Dong, H; Fyfe, MC; Gardner, LS; Kamikozawa, Y; Kurabayashi, S; Nawano, M; Ohashi, R; Procter, MJ; Qiu, L; Rasamison, CM; Schofield, KL; Shah, VK; Ueta, K; Williams, GM; Witter, D; Yasuda, K Glucokinase-activating ureas. Bioorg Med Chem Lett 15:1501-4 (2005) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
Gck | HXK4_RAT | Hexokinase type IV
Type:
PROTEIN
Mol. Mass.:
52101.81
Organism:
Rattus norvegicus
Description:
ChEMBL_1279785
Residue:
465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSVTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
  
Inhibitor
Name:
BDBM50161681
Synonyms:
3-(5-Chloro-thiazol-2-yl)-1-(6-cyano-pyridin-3-yl)-1-cyclopentylmethyl-urea | CHEMBL178162
Type:
Small organic molecule
Emp. Form.:
C16H16ClN5OS
Mol. Mass.:
361.849
SMILES:
Clc1cnc(NC(=O)N(CC2CCCC2)c2ccc(nc2)C#N)s1
Structure:
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