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Target
Tyrosine-protein phosphatase non-receptor type 6
Ligand
BDBM50162437
Substrate
n/a
Meas. Tech.
ChEMBL_302229 (CHEMBL827002)
Kd
210±n/a nM
Citation
 Imhof, D; Wieligmann, K; Hampel, K; Nothmann, D; Zoda, MS; Schmidt-Arras, D; Zacharias, M; Böhmer, FD; Reissmann, S Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1. J Med Chem 48:1528-39 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 6
Synonyms:
HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1)
Type:
Protein
Mol. Mass.:
67570.41
Organism:
Homo sapiens (Human)
Description:
P29350
Residue:
595
Sequence:
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
  
Inhibitor
Name:
BDBM50162437
Synonyms:
(4S)-4-amino-4-[({[(1S)-1-{[(8R,11R,14S,17S)-8-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-11-[2-(methylsulfanyl)ethyl]-2,5,10,13,16-pentaoxo-14-{[4-(phosphonooxy)phenyl]methyl}-1,3,9,12,15-pentaazacyclohenicosan-17-yl]carbamoyl}-3-methylbutyl]carbamoyl}methyl)carbamoyl]butanoic acid | CHEMBL408337
Type:
Small organic molecule
Emp. Form.:
C46H73N10O17PS
Mol. Mass.:
1101.167
SMILES:
CSCC[C@H]1NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)[C@H](CCCCNC(=O)NCC(=O)CC[C@@H](NC1=O)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCC(O)=O
Structure:
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