Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 6
Ligand
BDBM50162443
Substrate
n/a
Meas. Tech.
ChEMBL_304153 (CHEMBL828133)
EC50
80000±n/a nM
Citation
 Imhof, D; Wieligmann, K; Hampel, K; Nothmann, D; Zoda, MS; Schmidt-Arras, D; Zacharias, M; Böhmer, FD; Reissmann, S Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1. J Med Chem 48:1528-39 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 6
Synonyms:
HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1)
Type:
Protein
Mol. Mass.:
67570.41
Organism:
Homo sapiens (Human)
Description:
P29350
Residue:
595
Sequence:
MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
  
Inhibitor
Name:
BDBM50162443
Synonyms:
CHEMBL412186 | H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(betaPh)-NH2
Type:
Small organic molecule
Emp. Form.:
C46H68N9O16PS
Mol. Mass.:
1066.122
SMILES:
CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: