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Target
Serpin H1
Ligand
BDBM50162506
Substrate
n/a
Meas. Tech.
ChEMBL_305934 (CHEMBL833481)
IC50
6300±n/a nM
Citation
 Thomson, CA; Atkinson, HM; Ananthanarayanan, VS Identification of small molecule chemical inhibitors of the collagen-specific chaperone Hsp47. J Med Chem 48:1680-4 (2005) [PubMed]  Article 
Target
Name:
Serpin H1
Synonyms:
CBP1 | CBP2 | Collagen-binding protein 1 | HSP47 | SERPH_HUMAN | SERPINH1 | SERPINH2
Type:
PROTEIN
Mol. Mass.:
46451.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305934
Residue:
418
Sequence:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL
  
Inhibitor
Name:
BDBM50162506
Synonyms:
2-[2-(4-Chloro-3-methyl-phenyl)-2-oxo-ethylsulfanyl]-6-oxo-4-thiophen-2-yl-1,6-dihydro-pyrimidine-5-carbonitrile | CHEMBL195530
Type:
Small organic molecule
Emp. Form.:
C18H12ClN3O2S2
Mol. Mass.:
401.89
SMILES:
Cc1cc(ccc1Cl)C(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1
Structure:
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