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Target5-Hydroxytryptamine receptor 6 (5-HT6)
LigandBDBM50163052
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303258
Ki 1.9±n/a nM
Citation Holenz, JMercè, RDíaz, JLGuitart, XCodony, XDordal, ARomero, GTorrens, AMas, JAndaluz, BHernández, SMonroy, XSánchez, EHernández, EPérez, RCubí, RSanfeliu, OBuschmann, H Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. J Med Chem48:1781-95 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-Hydroxytryptamine receptor 6 (5-HT6)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM50163052
NameBDBM50163052
Synonyms:6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic acid [1-(2-dimethylamino-ethyl)-1H-indol-5-yl]-amide | CHEMBL175940
TypeSmall organic molecule
Emp. Form.C17H18ClN5O2S2
Mol. Mass.423.94
SMILESCN(C)CCn1ccc2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc12
Structure
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