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Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM50163185
Substrate
n/a
Meas. Tech.
ChEMBL_303638 (CHEMBL828848)
Ki
31±n/a nM
Citation
 Boger, DL; Miyauchi, H; Du, W; Hardouin, C; Fecik, RA; Cheng, H; Hwang, I; Hedrick, MP; Leung, D; Acevedo, O; Guimarães, CR; Jorgensen, WL; Cravatt, BF Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. J Med Chem 48:1849-56 (2005) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
  
Inhibitor
Name:
BDBM50163185
Synonyms:
(Z)-1-(4-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one | (Z)-1-(4-Pyridin-2-yl-oxazol-2-yl)-octadec-9-en-1-one | CHEMBL366671
Type:
Small organic molecule
Emp. Form.:
C26H38N2O2
Mol. Mass.:
410.5921
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)c1nc(co1)-c1ccccn1
Structure:
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