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Target
Matrix metalloproteinase-14
Ligand
BDBM50163809
Substrate
n/a
Meas. Tech.
ChEMBL_305128 (CHEMBL832424)
IC50
3±n/a nM
Citation
 Blagg, JA; Noe, MC; Wolf-Gouveia, LA; Reiter, LA; Laird, ER; Chang, SP; Danley, DE; Downs, JT; Elliott, NC; Eskra, JD; Griffiths, RJ; Hardink, JR; Haugeto, AI; Jones, CS; Liras, JL; Lopresti-Morrow, LL; Mitchell, PG; Pandit, J; Robinson, RP; Subramanyam, C; Vaughn-Bowser, ML; Yocum, SA Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Bioorg Med Chem Lett 15:1807-10 (2005) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-14
Synonyms:
MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase
Type:
Protein
Mol. Mass.:
65900.19
Organism:
Homo sapiens (Human)
Description:
P50281
Residue:
582
Sequence:
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
  
Inhibitor
Name:
BDBM50163809
Synonyms:
5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-oxazol-5-yl-phenoxy)-phenoxy]-piperidine-2,4,6-trione | CHEMBL367133
Type:
Small organic molecule
Emp. Form.:
C24H23N3O7
Mol. Mass.:
465.4553
SMILES:
CCOCCC1(Oc2ccc(Oc3ccc(cc3)-c3cnco3)cc2)C(=O)NC(=O)C(N)C1=O
Structure:
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