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Target
Procathepsin L
Ligand
BDBM50163831
Substrate
n/a
Meas. Tech.
ChEMBL_306022 (CHEMBL833537)
IC50
0.710000±n/a nM
Citation
 Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Shewchuk, LM; Tavares, FX; Willard, DH; Wright, LL Novel and potent cyclic cyanamide-based cathepsin K inhibitors. Bioorg Med Chem Lett 15:1815-9 (2005) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50163831
Synonyms:
(2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-carboxylate | CHEMBL183812
Type:
Small organic molecule
Emp. Form.:
C14H22N2O2
Mol. Mass.:
250.3367
SMILES:
C[C@@H](CC1CCCCC1)OC(=O)C1CCN1C#N
Structure:
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