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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50164232
Substrate
n/a
Meas. Tech.
ChEMBL_306714 (CHEMBL832299)
IC50
4.9±n/a nM
Citation
 de Dios, A; Shih, C; López de Uralde, B; Sánchez, C; del Prado, M; Martín Cabrejas, LM; Pleite, S; Blanco-Urgoiti, J; Lorite, MJ; Nevill, CR; Bonjouklian, R; York, J; Vieth, M; Wang, Y; Magnus, N; Campbell, RM; Anderson, BD; McCann, DJ; Giera, DD; Lee, PA; Schultz, RM; Li, LC; Johnson, LM; Wolos, JA Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy. J Med Chem 48:2270-3 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50164232
Synonyms:
6-(2-(2,6-difluorophenyl)-4-phenyl-1H-imidazol-5-yl)-1-(isopropylsulfonyl)-1H-benzo[d]imidazol-2-amine | 6-[2-(2,6-Difluoro-phenyl)-5-phenyl-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine | CHEMBL364572
Type:
Small organic molecule
Emp. Form.:
C25H21F2N5O2S
Mol. Mass.:
493.528
SMILES:
CC(C)S(=O)(=O)n1c(N)nc2ccc(cc12)-c1[nH]c(nc1-c1ccccc1)-c1c(F)cccc1F
Structure:
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