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Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50164246
Substrate
n/a
Meas. Tech.
ChEMBL_302592 (CHEMBL839552)
Ki
>3000±n/a nM
Citation
 McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem 48:2274-7 (2005) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50164246
Synonyms:
1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-butyl]-urea | CHEMBL190842
Type:
Small organic molecule
Emp. Form.:
C30H35F4N5O
Mol. Mass.:
557.6254
SMILES:
CN1CCN(CCCCN([C@@H]2CC[C@@]3(C[C@H]23)c2ccc(cc2)C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)CC1
Structure:
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