Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50165009
Substrate
n/a
Meas. Tech.
ChEMBL_302412 (CHEMBL875203)
Ki
>10000±n/a nM
Citation
 Kaur, K; Aeron, S; Bruhaspathy, M; Shetty, SJ; Gupta, S; Hegde, LH; Silamkoti, AD; Mehta, A; Chugh, A; Gupta, JB; Sarma, PK; Kumar, N Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine. Bioorg Med Chem Lett 15:2093-6 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50165009
Synonyms:
(1R,5S)-3-[3-(2-Benzyloxy-5-methyl-phenyl)-3-phenyl-propyl]-3-aza-bicyclo[3.1.0]hexane | CHEMBL363865
Type:
Small organic molecule
Emp. Form.:
C28H31NO
Mol. Mass.:
397.5518
SMILES:
Cc1ccc(OCc2ccccc2)c(c1)C(CCN1C[C@@H]2C[C@@H]2C1)c1ccccc1
Structure:
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