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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50165016
Substrate
n/a
Meas. Tech.
ChEMBL_302413 (CHEMBL828817)
Ki
79.0±n/a nM
Citation
 Kaur, K; Aeron, S; Bruhaspathy, M; Shetty, SJ; Gupta, S; Hegde, LH; Silamkoti, AD; Mehta, A; Chugh, A; Gupta, JB; Sarma, PK; Kumar, N Design, synthesis and activity of novel derivatives of oxybutynin and tolterodine. Bioorg Med Chem Lett 15:2093-6 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66086.66
Organism:
RAT
Description:
Cholinergic, muscarinic M3 CHRM3 RAT::P08483
Residue:
589
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50165016
Synonyms:
4-Methyl-2-[3-((1R,5S)-2-methyl-3-aza-bicyclo[3.1.0]hex-3-yl)-1-phenyl-propyl]-phenol | CHEMBL192061
Type:
Small organic molecule
Emp. Form.:
C22H27NO
Mol. Mass.:
321.4559
SMILES:
CC1[C@@H]2C[C@@H]2CN1CCC(c1ccccc1)c1cc(C)ccc1O
Structure:
Search PDB for entries with ligand similarity: