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Target
Neuraminidase
Ligand
BDBM50165355
Substrate
n/a
Meas. Tech.
ChEMBL_305818 (CHEMBL829471)
IC50
0.77±n/a nM
Citation
 Macdonald, SJ; Cameron, R; Demaine, DA; Fenton, RJ; Foster, G; Gower, D; Hamblin, JN; Hamilton, S; Hart, GJ; Hill, AP; Inglis, GG; Jin, B; Jones, HT; McConnell, DB; McKimm-Breschkin, J; Mills, G; Nguyen, V; Owens, IJ; Parry, N; Shanahan, SE; Smith, D; Watson, KG; Wu, WY; Tucker, SP Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza. J Med Chem 48:2964-71 (2005) [PubMed]  Article 
Target
Name:
Neuraminidase
Synonyms:
Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A
Type:
Enzyme
Mol. Mass.:
50124.14
Organism:
Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1))
Description:
P03468
Residue:
454
Sequence:
MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNSTWVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKIFKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIWDPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKTIWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
  
Inhibitor
Name:
BDBM50165355
Synonyms:
(2R,4S)-3-(acetylamino)-4-{[(E)-amino(imino)methyl]amino}-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | CHEMBL193303
Type:
Small organic molecule
Emp. Form.:
C12H20N4O7
Mol. Mass.:
332.3098
SMILES:
[#6]-[#6](=O)-[#7]-[#6]-1-[#6@H](-[#6]=[#6](-[#8]-[#6@H]-1-[#6@H](-[#8])-[#6](-[#8])-[#6]-[#8])-[#6](-[#8])=O)\[#7]=[#6](\[#7])-[#7] |c:6|
Structure:
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