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Target
Choline kinase alpha
Ligand
BDBM50166189
Substrate
n/a
Meas. Tech.
ChEMBL_305138 (CHEMBL832433)
IC50
2300±n/a nM
Citation
 Sánchez-Martín, R; Campos, JM; Conejo-García, A; Cruz-López, O; Báñez-Coronel, M; Rodríguez-González, A; Gallo, MA; Lacal, JC; Espinosa, A Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line. J Med Chem 48:3354-63 (2005) [PubMed]  Article 
Target
Name:
Choline kinase alpha
Synonyms:
CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha
Type:
PROTEIN
Mol. Mass.:
52248.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290064
Residue:
457
Sequence:
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
  
Inhibitor
Name:
BDBM50166189
Synonyms:
Bisquinolinium derivative | CHEMBL364022
Type:
Small organic molecule
Emp. Form.:
C46H40N4
Mol. Mass.:
648.8355
SMILES:
C(Cc1ccc(Cn2cc\c(=[NH+]/c3ccccc3)c3ccccc23)cc1)c1ccc(Cn2cc\c(=[NH+]\c3ccccc3)c3ccccc23)cc1
Structure:
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