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Target
Choline kinase alpha
Ligand
BDBM50166177
Substrate
n/a
Meas. Tech.
ChEMBL_305138 (CHEMBL832433)
IC50
5700±n/a nM
Citation
 Sánchez-Martín, R; Campos, JM; Conejo-García, A; Cruz-López, O; Báñez-Coronel, M; Rodríguez-González, A; Gallo, MA; Lacal, JC; Espinosa, A Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line. J Med Chem 48:3354-63 (2005) [PubMed]  Article 
Target
Name:
Choline kinase alpha
Synonyms:
CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha
Type:
PROTEIN
Mol. Mass.:
52248.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1290064
Residue:
457
Sequence:
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
  
Inhibitor
Name:
BDBM50166177
Synonyms:
Bisquinolinium derivative | CHEMBL364692
Type:
Small organic molecule
Emp. Form.:
C46H36Cl4N4
Mol. Mass.:
786.616
SMILES:
C\[N+](c1ccc(Cl)cc1)=c1\ccn(Cc2cccc(c2)-c2cccc(Cn3cc\c(=[N+](/C)c4ccc(Cl)cc4)c4ccc(Cl)cc34)c2)c2cc(Cl)ccc12
Structure:
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