Reaction Details Report a problem with these data
Target
Glutamate receptor ionotropic, kainate 3
Ligand
BDBM17662
Substrate
n/a
Meas. Tech.
ChEMBL_310490 (CHEMBL834064)
EC50
3800±n/a nM
Citation
 Vogensen, SB; Clausen, RP; Greenwood, JR; Johansen, TN; Pickering, DS; Nielsen, B; Ebert, B; Krogsgaard-Larsen, P Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues. J Med Chem 48:3438-42 (2005) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 3
Synonyms:
GRIK3_RAT | Glur7 | Glutamate receptor ionotropic kainate 3 | Glutamate receptor ionotropic, kainate | Grik3
Type:
PROTEIN
Mol. Mass.:
104080.46
Organism:
Rattus norvegicus
Description:
ChEMBL_1447329
Residue:
919
Sequence:
MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNAHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRASQMTVNSLQCHRHKPWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP
  
Inhibitor
Name:
BDBM17662
Synonyms:
(2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid | 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid | AMPA | CHEMBL276815
Type:
Small organic molecule
Emp. Form.:
C7H10N2O4
Mol. Mass.:
186.1653
SMILES:
Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: