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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50167550
Substrate
n/a
Meas. Tech.
ChEMBL_306352 (CHEMBL828171)
IC50
41.3±n/a nM
Citation
 Souers, AJ; Gao, J; Wodka, D; Judd, AS; Mulhern, MM; Napier, JJ; Brune, ME; Bush, EN; Brodjian, SJ; Dayton, BD; Shapiro, R; Hernandez, LE; Marsh, KC; Sham, HL; Collins, CA; Kym, PR Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Bioorg Med Chem Lett 15:2752-7 (2005) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
Gpr24 | MCHR1_MOUSE | Mchr1 | Slc1
Type:
PROTEIN
Mol. Mass.:
39133.74
Organism:
Mus musculus
Description:
ChEMBL_818502
Residue:
353
Sequence:
MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50167550
Synonyms:
1-(4-Benzyloxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-5-yl]-urea | CHEMBL370839
Type:
Small organic molecule
Emp. Form.:
C27H29N5O2
Mol. Mass.:
455.5515
SMILES:
O=C(Nc1ccc(OCc2ccccc2)cc1)Nc1ccc2n(CCN3CCCC3)ncc2c1
Structure:
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