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Target
RNA-directed RNA polymerase
Ligand
BDBM50166407
Substrate
n/a
Meas. Tech.
ChEMBL_306492 (CHEMBL827995)
IC50
30±n/a nM
Citation
Pfefferkorn, JA; Nugent, R; Gross, RJ; Greene, M; Mitchell, MA; Reding, MT; Funk, LA; Anderson, R; Wells, PA; Shelly, JA; Anstadt, R; Finzel, BC; Harris, MS; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorg Med Chem Lett 15:2812-8 (2005) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50166407
Synonyms:
(Z)-2-Benzoylamino-3-[4-(2-bromo-6-fluoro-phenoxy)-phenyl]-acrylic acid | 2-benzamido-3-(4-(2-bromo-6-fluorophenoxy)phenyl)acrylic acid | CHEMBL366197
Type:
Small organic molecule
Emp. Form.:
C22H15BrFNO4
Mol. Mass.:
456.261
SMILES:
OC(=O)C(\NC(=O)c1ccccc1)=C\c1ccc(Oc2c(F)cccc2Br)cc1