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Target
Glucocorticoid receptor
Ligand
BDBM50167794
Substrate
n/a
Meas. Tech.
ChEMBL_304659 (CHEMBL827860)
IC50
73±n/a nM
Citation
 Smith, CJ; Ali, A; Balkovec, JM; Graham, DW; Hammond, ML; Patel, GF; Rouen, GP; Smith, SK; Tata, JR; Einstein, M; Ge, L; Harris, GS; Kelly, TM; Mazur, P; Thompson, CM; Wang, CF; Williamson, JM; Miller, DK; Pandit, S; Santoro, JC; Sitlani, A; Yamin, TT; O'Neill, EA; Zaller, DM; Carballo-Jane, E; Forrest, MJ; Luell, S Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity. Bioorg Med Chem Lett 15:2926-31 (2005) [PubMed]  Article 
Target
Name:
Glucocorticoid receptor
Synonyms:
GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:
Enzyme
Mol. Mass.:
85656.87
Organism:
Homo sapiens (Human)
Description:
P04150
Residue:
777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
  
Inhibitor
Name:
BDBM50167794
Synonyms:
1-(4-fluorophenyl)-4a-methyl-(4aS)-spiro[1,4,4a,5,6,7-hexahydrocyclopenta[f]indazole-5,2'-(dihydro[1,3]dioxolane)] | 1-(4-fluorophenyl)-4a-methylspiro[1,4,4a,5,6,7-hexahydrocyclopenta[f]indazole-5,2'-(dihydro[1,3]dioxolane)] | CHEMBL371311
Type:
Small organic molecule
Emp. Form.:
C19H19FN2O2
Mol. Mass.:
326.3648
SMILES:
C[C@]12Cc3cnn(c3C=C1CCC21OCCO1)-c1ccc(F)cc1 |c:9|
Structure:
Search PDB for entries with ligand similarity: