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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50089379
Substrate
n/a
Meas. Tech.
ChEMBL_306024 (CHEMBL833539)
IC50
40±n/a nM
Citation
 Migawa, MT; Drach, JC; Townsend, LB Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of tri J Med Chem 48:3840-51 (2005) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50089379
Synonyms:
(2R,3R,4S,5R)-2-(3-Amino-5-methyl-5H-1,4,5,6,8-pentaaza-acenaphthylen-1-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | (3R,4S,5R)-2-((R)-3-Amino-5-methyl-5H-1,4,5,6,8-pentaaza-acenaphthylen-1-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | 2-(3-Amino-5-methyl-5H-1,4,5,6,8-pentaaza-acenaphthylen-1-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | CHEMBL331237 | NSC-154020 | TRICIRIBINE
Type:
Small organic molecule
Emp. Form.:
C13H16N6O4
Mol. Mass.:
320.3039
SMILES:
Cn1nc(N)c2cn(C3O[C@H](CO)[C@H](O)[C@@H]3O)c3ncnc1c23
Structure:
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