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Target
Ribosomal protein S6 kinase alpha-5
Ligand
BDBM50168586
Substrate
n/a
Meas. Tech.
ChEMBL_304581 (CHEMBL828472)
IC50
55±n/a nM
Citation
 Bamford, MJ; Alberti, MJ; Bailey, N; Davies, S; Dean, DK; Gaiba, A; Garland, S; Harling, JD; Jung, DK; Panchal, TA; Parr, CA; Steadman, JG; Takle, AK; Townsend, JT; Wilson, DM; Witherington, J (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg Med Chem Lett 15:3402-6 (2005) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase alpha-5
Synonyms:
90 kDa ribosomal protein S6 kinase 5 | KS6A5_HUMAN | MSK1 | Mitogen- and Stress-Activated Protein Kinase 1 (MSK1) | Nuclear mitogen- and stress-activated protein kinase 1 | Nuclear mitogen- and stress-activated protein kinase 1 (MSK1) | RPS6KA5 | RPS6KA5(Kin.Dom.2 - C-terminal) | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha 5 | Ribosomal protein S6 kinase alpha-5
Type:
Serine/threonine-protein kinase
Mol. Mass.:
89874.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
802
Sequence:
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
  
Inhibitor
Name:
BDBM50168586
Synonyms:
4-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-5-methyl-1H-pyrazol-3-ylamine | CHEMBL361678
Type:
Small organic molecule
Emp. Form.:
C12H14N6
Mol. Mass.:
242.2798
SMILES:
CCn1c(nc2cnccc12)-c1c(C)[nH]nc1N |(11.15,-8.55,;12.2,-7.41,;11.71,-5.96,;12.62,-4.7,;11.71,-3.45,;10.24,-3.93,;8.92,-3.16,;7.59,-3.93,;7.59,-5.48,;8.92,-6.24,;10.24,-5.48,;14.15,-4.58,;15.15,-5.75,;14.78,-7.24,;16.57,-5.17,;16.46,-3.64,;14.97,-3.26,;14.39,-1.85,)|
Structure:
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