Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 22
Ligand
BDBM50168887
Substrate
n/a
Meas. Tech.
ChEMBL_305310 (CHEMBL831701)
IC50
60000±n/a nM
Citation
 Cutshall, NS; O'Day, C; Prezhdo, M Rhodanine derivatives as inhibitors of JSP-1. Bioorg Med Chem Lett 15:3374-9 (2005) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 22
Synonyms:
DUS22_HUMAN | DUSP22 | Dual specificity phosphatase 22 | Dual specificity protein phosphatase (MKPX) | Dual specificity protein phosphatase 22 | Dual specificity protein phosphatase 22 (VHX) | Dual specificity protein phosphatase VHX (VHX) | JSP1 | LMWDSP2 | MKPX | Mitogen-activated protein kinase phosphatase x | VHX
Type:
Protein
Mol. Mass.:
20915.83
Organism:
Homo sapiens (Human)
Description:
Q9NRW4
Residue:
184
Sequence:
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL
  
Inhibitor
Name:
BDBM50168887
Synonyms:
4-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-3-ylmethyl}-benzoic acid | CHEMBL362391
Type:
Small organic molecule
Emp. Form.:
C18H13NO3S2
Mol. Mass.:
355.431
SMILES:
OC(=O)c1ccc(CN2C(=S)S\C(=C/c3ccccc3)C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: