Reaction Details Report a problem with these data
Target
alpha-1,2-Mannosidase
Ligand
BDBM50168990
Substrate
n/a
Meas. Tech.
ChEMBL_305169 (CHEMBL832759)
IC50
128000±n/a nM
Citation
 Fiaux, H; Popowycz, F; Favre, S; Schütz, C; Vogel, P; Gerber-Lemaire, S; Juillerat-Jeanneret, L Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. J Med Chem 48:4237-46 (2005) [PubMed]  Article 
Target
Name:
alpha-1,2-Mannosidase
Synonyms:
Alpha-mannosidase
Type:
PROTEIN
Mol. Mass.:
65344.50
Organism:
Glycine max
Description:
ChEMBL_32380
Residue:
578
Sequence:
MARGSRSVGSSSSKWRYCNPSYYLKRPKRLALLFIVFVCVSFVFWDRQTLVREHQVEISELQKEVTDLKNLVDDLNNKQGGTSGKTDLGRKATKSSKDVLDDPIDIERREKVKEAMLHAWGSYEKYAWGQDELQPQSKNGVNSFGGLGATLIDSLDTLYIMGLNEQFQKAREWVANSLDFNKDYEASVFETTIRVVGGLLSAYDLSGDKVFLDKAIEIADRLLPAWNTPTGIPYNIINLSHGRAHNPSWTGGESILADSGTEQLEFIVLSQRTGDLKYQQKVENVIAQLNKTFPDDGLLPIYINPHSGAAGYSPITFGAMGDSFYEYLLKVWIQGNKTSSIKHYRDMWEKSMKGLSSLIRRSTPSSFTYICEKNGGSLTDKMDELACFAPGMIALGSFGYSAADDSQKFLSLAEELAWTCYNFYQSTPTKLAGENYFFHSGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFQAFEKNSRIESGYVGLKDVNSGVKDNMMQSFFLAETLKYFYLLFSPSSVISLDEWVFNTEAHPLRIVTRHEEGLVKNLNEKQKPFSRIGGRKEGRSG
  
Inhibitor
Name:
BDBM50168990
Synonyms:
(2R,3R,4S)-2-[((R)-Phenyl-1-(S)-2-hydroxy-2-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol | CHEMBL361899
Type:
Small organic molecule
Emp. Form.:
C19H24N2O3
Mol. Mass.:
328.4055
SMILES:
O[C@@H]([C@@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: