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Target
Methionine aminopeptidase
Ligand
BDBM50170359
Substrate
n/a
Meas. Tech.
ChEMBL_304984 (CHEMBL829421)
IC50
61±n/a nM
Citation
 Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives. Bioorg Med Chem Lett 15:4130-5 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50170359
Synonyms:
5-(Methoxy-phenyl-methyl)-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL190342
Type:
Small organic molecule
Emp. Form.:
C15H13N3O2S2
Mol. Mass.:
331.413
SMILES:
COC(c1scnc1C(=O)Nc1nccs1)c1ccccc1
Structure:
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