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Target
Methionine aminopeptidase 1
Ligand
BDBM50170369
Substrate
n/a
Meas. Tech.
ChEMBL_304990 (CHEMBL828603)
IC50
150±n/a nM
Citation
 Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives. Bioorg Med Chem Lett 15:4130-5 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1
Type:
PROTEIN
Mol. Mass.:
43382.92
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_10701
Residue:
387
Sequence:
MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYKAHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQRNDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYPSPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGENISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFFHCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHTLLVTEHGVEILTARNKKSPGGPRQRIK
  
Inhibitor
Name:
BDBM50170369
Synonyms:
5-(2-Ethoxy-3-methyl-butyl)-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL363943
Type:
Small organic molecule
Emp. Form.:
C14H19N3O2S2
Mol. Mass.:
325.45
SMILES:
CCOC(Cc1scnc1C(=O)Nc1nccs1)C(C)C
Structure:
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