Reaction Details Report a problem with these data
Target
Methionine aminopeptidase
Ligand
BDBM50170388
Substrate
n/a
Meas. Tech.
ChEMBL_304984 (CHEMBL829421)
IC50
36±n/a nM
Citation
 Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives. Bioorg Med Chem Lett 15:4130-5 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50170388
Synonyms:
5-((R)-2-Methoxy-2-phenyl-ethyl)-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL361480
Type:
Small organic molecule
Emp. Form.:
C16H15N3O2S2
Mol. Mass.:
345.439
SMILES:
CO[C@H](Cc1scnc1C(=O)Nc1nccs1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: