Reaction Details
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50170742
Substrate
n/a
Meas. Tech.
ChEMBL_302233 (CHEMBL827006)
Kd
66000±n/a nM
Citation
Smet, C; Duckert, JF; Wieruszeski, JM; Landrieu, I; Buée, L; Lippens, G; Déprez, B Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides. J Med Chem 48:4815-23 (2005) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50170742
Synonyms:
CHEMBL187793 | [(S)-1-((S)-2-Carbamoyl-2,5-dihydro-pyrrole-1-carbonyl)-2-phosphonooxy-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C24H26N3O8P
Mol. Mass.:
515.4523
SMILES:
C[C@@H](OP(O)(O)=O)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N1CC=C[C@H]1C(N)=O |c:33|
Structure:
