Reaction Details
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50170746
Substrate
n/a
Meas. Tech.
ChEMBL_302233 (CHEMBL827006)
Kd
>2000000±n/a nM
Citation
Smet, C; Duckert, JF; Wieruszeski, JM; Landrieu, I; Buée, L; Lippens, G; Déprez, B Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides. J Med Chem 48:4815-23 (2005) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50170746
Synonyms:
4-Acetylamino-5-((S)-2-carbamoyl-pyrrolidin-1-yl)-5-oxo-pentanoic acid | CHEMBL187767
Type:
Small organic molecule
Emp. Form.:
C12H19N3O5
Mol. Mass.:
285.2964
SMILES:
CC(=O)NC(CCC(O)=O)C(=O)N1CCC[C@H]1C(N)=O
Structure:
