Reaction Details
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50170749
Substrate
n/a
Meas. Tech.
ChEMBL_302233 (CHEMBL827006)
Kd
30000±n/a nM
Citation
Smet, C; Duckert, JF; Wieruszeski, JM; Landrieu, I; Buée, L; Lippens, G; Déprez, B Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides. J Med Chem 48:4815-23 (2005) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50170749
Synonyms:
CHEMBL189818 | Phosphoric acid mono-[(1S,3S)-3-(2-carbamoyl-pyrrolidin-1-yl)-1-methyl-3-oxo-2-((R)-4-phenyl-butyrylamino)-propyl] ester
Type:
Small organic molecule
Emp. Form.:
C19H28N3O7P
Mol. Mass.:
441.4153
SMILES:
C[C@@H](OP(O)(O)=O)[C@H](NC(=O)CCCc1ccccc1)C(=O)N1CCC[C@H]1C(N)=O
Structure:
