Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50171987
Substrate
n/a
Meas. Tech.
ChEBML_310805
EC50
>3000±n/a nM
Citation
Shi, GQ; Dropinski, JF; Zhang, Y; Santini, C; Sahoo, SP; Berger, JP; Macnaul, KL; Zhou, G; Agrawal, A; Alvaro, R; Cai, TQ; Hernandez, M; Wright, SD; Moller, DE; Heck, JV; Meinke, PT Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity. J Med Chem 48:5589-99 (2005) [PubMed] Article
More Info.:
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA | PPARA_CANLF
Type:
PROTEIN
Mol. Mass.:
52119.89
Organism:
Canis familiaris
Description:
ChEMBL_796444
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFSFTEYQYLGSGPGSDGSVITDTLSPAPSPSSVTHPAAPGGAEEPSSVALNIECRICGDRASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEQDPEDAETADLKSLAKRIYEAYLKNFNMNKVKARVILAGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLKLHLQTNHPDNIFLFPKLLQKMADLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
Inhibitor
Name:
BDBM50171987
Synonyms:
2-Benzyl-5-[3-(2-chloro-4-trifluoromethoxy-phenoxy)-propoxy]-2,3-dihydro-benzofuran-2-carboxylic acid | CHEMBL192774
Type:
Small organic molecule
Emp. Form.:
C26H22ClF3O6
Mol. Mass.:
522.897
SMILES:
OC(=O)C1(Cc2ccccc2)Cc2cc(OCCCOc3ccc(OC(F)(F)F)cc3Cl)ccc2O1