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Target
Branched-chain-amino-acid aminotransferase, mitochondrial
Ligand
BDBM50172933
Substrate
n/a
Meas. Tech.
ChEMBL_348857 (CHEMBL866890)
IC50
3000±n/a nM
Citation
 Hu, LY; Boxer, PA; Kesten, SR; Lei, HJ; Wustrow, DJ; Moreland, DW; Zhang, L; Ahn, K; Ryder, TR; Liu, X; Rubin, JR; Fahnoe, K; Carroll, RT; Dutta, S; Fahnoe, DC; Probert, AW; Roof, RL; Rafferty, MF; Kostlan, CR; Scholten, JD; Hood, M; Ren, XD; Schielke, GP; Su, TZ; Taylor, CP; Mistry, A; McConnell, P; Hasemann, C; Ohren, J The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett 16:2337-40 (2006) [PubMed]  Article 
Target
Name:
Branched-chain-amino-acid aminotransferase, mitochondrial
Synonyms:
BCAT2_RAT | Bcat2 | Bcatm | Branched-chain-amino-acid transferase | Eca40
Type:
PROTEIN
Mol. Mass.:
44283.08
Organism:
Rattus norvegicus
Description:
ChEMBL_348857
Residue:
393
Sequence:
MSAAILGQVWTRKLLPIPWRLCVPGRCVSSNFKAADLQVQVTREPQKKPAPSQPLLFGKTFTDHMLMVEWNSKTGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGRDKQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLFVILCPVGSYFPGDSMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQQEAQKKGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGELELATPPLDGIILPGVVRQSLLDLARTWGEFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRFQKELKAIQYGTSAHDWMLRV
  
Inhibitor
Name:
BDBM50172933
Synonyms:
5-chloro-N'-(2-(trifluoromethyl)phenylsulfonyl)-1H-indole-2-carbohydrazide | CHEMBL205903
Type:
Small organic molecule
Emp. Form.:
C16H11ClF3N3O3S
Mol. Mass.:
417.79
SMILES:
FC(F)(F)c1ccccc1S(=O)(=O)NNC(=O)c1cc2cc(Cl)ccc2[nH]1
Structure:
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