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Target
Branched-chain-amino-acid aminotransferase, cytosolic
Ligand
BDBM50172937
Substrate
n/a
Meas. Tech.
ChEMBL_348855 (CHEMBL866887)
IC50
15000±n/a nM
Citation
 Hu, LY; Boxer, PA; Kesten, SR; Lei, HJ; Wustrow, DJ; Moreland, DW; Zhang, L; Ahn, K; Ryder, TR; Liu, X; Rubin, JR; Fahnoe, K; Carroll, RT; Dutta, S; Fahnoe, DC; Probert, AW; Roof, RL; Rafferty, MF; Kostlan, CR; Scholten, JD; Hood, M; Ren, XD; Schielke, GP; Su, TZ; Taylor, CP; Mistry, A; McConnell, P; Hasemann, C; Ohren, J The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett 16:2337-40 (2006) [PubMed]  Article 
Target
Name:
Branched-chain-amino-acid aminotransferase, cytosolic
Synonyms:
BCAT1 | BCAT1_HUMAN | BCT1 | Branched-chain-amino-acid transferase | ECA39
Type:
PROTEIN
Mol. Mass.:
42957.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1516919
Residue:
386
Sequence:
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
  
Inhibitor
Name:
BDBM50172937
Synonyms:
5-bromo-N'-(phenylsulfonyl)-1H-indole-2-carbohydrazide | CHEMBL207583
Type:
Small organic molecule
Emp. Form.:
C15H12BrN3O3S
Mol. Mass.:
394.243
SMILES:
Brc1ccc2[nH]c(cc2c1)C(=O)NNS(=O)(=O)c1ccccc1
Structure:
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