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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50173824
Substrate
n/a
Meas. Tech.
ChEMBL_321126 (CHEMBL884981)
pH
7.8±n/a
EC50
>100000±n/a nM
Comments
extracted
Citation
 Kaur, N; Lu, X; Gershengorn, MC; Jain, R Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2. J Med Chem 48:6162-5 (2005) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_RAT | Thyroliberin receptor | Trhr
Type:
PROTEIN
Mol. Mass.:
46618.79
Organism:
Rattus norvegicus
Description:
ChEMBL_303571
Residue:
412
Sequence:
MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
  
Inhibitor
Name:
BDBM50173824
Synonyms:
1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide | CHEMBL369944
Type:
Small organic molecule
Emp. Form.:
C26H36N6O4
Mol. Mass.:
496.6018
SMILES:
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc([nH]1)C12CC3CC(CC(C3)C1)C2)NC(=O)[C@@H]1CCC(=O)N1 |TLB:24:19:26:25.23.22,24:23:26:18.19.20,THB:22:21:18:25.23.24,22:23:18:26.21.20|
Structure:
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