Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50174050
Substrate
n/a
Meas. Tech.
ChEMBL_320947 (CHEMBL882466)
Ki
40±n/a nM
Citation
 Fisher, MJ; Backer, RT; Collado, I; de Frutos, O; Husain, S; Hsiung, HM; Kuklish, SL; Mateo, AI; Mullaney, JT; Ornstein, PL; Paredes, CG; O'Brian, TP; Richardson, TI; Shah, J; Zgombick, JM; Briner, K Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives. Bioorg Med Chem Lett 15:4973-8 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50174050
Synonyms:
CHEMBL365184 | Diethyl-[2-(4-methyl-piperazin-1-yl)-2-(2-trifluoromethyl-phenyl)-ethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C18H28F3N3
Mol. Mass.:
343.4302
SMILES:
CCN(CC)CC(N1CCN(C)CC1)c1ccccc1C(F)(F)F
Structure:
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