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Target
Sodium/glucose cotransporter 2
Ligand
BDBM50174675
Substrate
n/a
Meas. Tech.
ChEMBL_326560 (CHEMBL863286)
IC50
491±n/a nM
Citation
 Zhang, X; Urbanski, M; Patel, M; Zeck, RE; Cox, GG; Bian, H; Conway, BR; Pat Beavers, M; Rybczynski, PJ; Demarest, KT Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1. Bioorg Med Chem Lett 15:5202-6 (2005) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:
Protein
Mol. Mass.:
72902.00
Organism:
Homo sapiens (Human)
Description:
P31639
Residue:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
  
Inhibitor
Name:
BDBM50174675
Synonyms:
(2S,3R,4S,5S,6R)-2-(3-(2-(benzofuran-5-yl)ethyl)-6-methyl-1H-indazol-4-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol | CHEMBL371448
Type:
Small organic molecule
Emp. Form.:
C24H26N2O7
Mol. Mass.:
454.4724
SMILES:
Cc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(CCc3ccc4occc4c3)n[nH]c2c1
Structure:
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