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TargetCdc25C
LigandBDBM24778
Substrate/Competitorn/a
Meas. Tech.ChEMBL_328904
IC50 19000±n/a nM
Citation Lavergne, OFernandes, ACBréhu, LSidhu, ABrézak, MCPrévost, GDucommun, BContour-Galcera, MO Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett16:171-5 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cdc25C
Name:Cdc25C
Synonyms:Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3
Type:Substrate
Mol. Mass.:53366.11
Organism:Homo sapiens (Human)
Description:P30307
Residue:473
Sequence:
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANL
SILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMK
CSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNP
NLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDK
VKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQ
DLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKK
PIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFF
PEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
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  Blast E-value cutoff:
BDBM24778
n/a
NameBDBM24778
Synonyms:2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-methyl-1,4-naphthoquinone, 5 | CHEMBL590 | Menadione | Menadione (5d) | Menadione (Vitamin K3) | Menadione, 9 | Vitamin K3 | cid_4055
TypeSmall organic molecule
Emp. Form.C11H8O2
Mol. Mass.172.18
SMILESCC1=CC(=O)c2ccccc2C1=O |t:1|
Structure
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