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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50175705
Substrate
n/a
Meas. Tech.
ChEMBL_328177 (CHEMBL863943)
IC50
22000±n/a nM
Citation
 Weide, T; Arve, L; Prinz, H; Waldmann, H; Kessler, H 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorg Med Chem Lett 16:59-63 (2005) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50175705
Synonyms:
3-((S)-2-(3-benzoyl-1-cyanoindolizin-5-yloxy)-4-methylpentanamido)-3-phenylpropanoic acid | CHEMBL372159
Type:
Small organic molecule
Emp. Form.:
C31H29N3O5
Mol. Mass.:
523.5791
SMILES:
CC(C)C[C@H](Oc1cccc2c(cc(C(=O)c3ccccc3)n12)C#N)C(=O)NC(CC(O)=O)c1ccccc1
Structure:
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