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Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50176190
Substrate
n/a
Meas. Tech.
ChEMBL_330757 (CHEMBL861921)
IC50
1780±n/a nM
Citation
 Cheng, JF; Chen, M; Liu, B; Hou, Z; Arrhenius, T; Nadzan, AM Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett 16:695-700 (2005) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50176190
Synonyms:
2-(4-(5-amino-3-(furan-3-yl)isoxazol-4-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol | CHEMBL201105
Type:
Small organic molecule
Emp. Form.:
C16H10F6N2O3
Mol. Mass.:
392.2526
SMILES:
Nc1onc(-c2ccoc2)c1-c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: