Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 1
Ligand
BDBM50176389
Substrate
n/a
Meas. Tech.
ChEMBL_333862 (CHEMBL864091)
IC50
476±n/a nM
Citation
 Durgam, GG; Tsukahara, R; Makarova, N; Walker, MD; Fujiwara, Y; Pigg, KR; Baker, DL; Sardar, VM; Parrill, AL; Tigyi, G; Miller, DD Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands. Bioorg Med Chem Lett 16:633-40 (2005) [PubMed]  Article 
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM50176389
Synonyms:
CHEMBL440396 | thiophosphoric acid (S)-2-octanoylamino-2-octylcarbamoyl-ethyl ester
Type:
Small organic molecule
Emp. Form.:
C19H39N2O5PS
Mol. Mass.:
438.562
SMILES:
CCCCCCCCNC(=O)[C@H](COP(O)(O)=S)NC(=O)CCCCCCC
Structure:
Search PDB for entries with ligand similarity: