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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM28393
Substrate
n/a
Meas. Tech.
ChEMBL_327541 (CHEMBL854356)
IC50
>16000±n/a nM
Citation
 Chambers, RJ; Abrams, K; Garceau, NY; Kamath, AV; Manley, CM; Lilley, SC; Otte, DA; Scott, DO; Sheils, AL; Tess, DA; Vellekoop, AS; Zhang, Y; Lam, KT A new chemical tool for exploring the physiological function of the PDE2 isozyme. Bioorg Med Chem Lett 16:307-10 (2005) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D
Type:
Protein
Mol. Mass.:
91092.69
Organism:
Homo sapiens (Human)
Description:
Q08499
Residue:
809
Sequence:
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
  
Inhibitor
Name:
BDBM28393
Synonyms:
(+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol | CHEMBL296435
Type:
Small organic molecule
Emp. Form.:
C14H23N5O
Mol. Mass.:
277.3653
SMILES:
CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12 |r|
Structure:
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